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By use of macro-economic model EXIOMOD, the expected impacts of actions described in the Strategic Research and Innovation Agenda (SRIA) have been analyzed. The results of this analysis show that the R&I actions described in the SRIA contribute to decoupling economic growth from resource use. The actions are expected to cause an increasing gross domestic product and a decreasing raw material demand. This results in an increasing extracted resource productivity, a measure used to show the decoupling of economic growth and resource use. It can however be questioned whether the actions in the SRIA - or the measures implemented in the model - assume a strong enough pace for decoupling economic growth and material use. The actions contribute to the climate goals of the European Commission, by showing a pathway through which the emissions of greenhouse gas can be reduced.